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Honey, in general, has been used in health through history, only falling out of medical favour in the 1900s with the rise of modern antibiotics (1).
With the increased use of antibiotics and antibacterial products more and more bugs are becoming resistant to current treatments (2).

Manuka honey, as we have come to know, is a special type of honey made by bees that feast on the nectar of a special tree found in Australia and New Zealand.
It is known as Leptospermum scoparium. This article contains a detailed description of how this special substance is made, where it is found and its origins.